{"id":761,"date":"2023-10-18T11:14:48","date_gmt":"2023-10-18T02:14:48","guid":{"rendered":"https:\/\/adelpharm.mycafe24.com\/?page_id=761"},"modified":"2023-10-19T13:06:04","modified_gmt":"2023-10-19T04:06:04","slug":"adel-y04","status":"publish","type":"page","link":"https:\/\/adelpharm.com\/en\/adel-y04\/","title":{"rendered":"ADEL-Y04"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container fusion-parallax-none nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-image: url(&quot;https:\/\/adelpharm.com\/wp-content\/uploads\/pipeline_subbanner_bg.jpg&quot;);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#e2e2e2;border-style:solid;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;\" id=\"subbanner\"><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:calc( 1300px + 0px );margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInDown\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-1\" style=\"text-align:center;\" id=\"subbanner_txtbox\"><p class=\"page_parent\">Pipeline<\/p>\n<h1 class=\"page_h1\">ADEL-Y04<\/h1>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-0{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-0 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-0{width:100% !important;order : 0;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-0{width:100% !important;order : 0;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}<\/style><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 230px;margin-top : 0px;padding-right : 0px;padding-bottom : 0px;margin-bottom : 0px;padding-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 210px;}}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#e2e2e2;border-style:solid;\" id=\"subpage_con1\"><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:calc( 1300px + 0px );margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;background-color:#ffffff;padding: 60px 0px 126px 0px;\"><ul class=\"breadcrumbs_list\">\n    <li><a href=\"\/en\/home\" class=\"bread_home\"><span class=\"sr_only\">HOME<\/span><\/a><\/li>\n    <li><a href=\"\/en\/pipeline\">PIPELINE<\/a><\/li>\n    <li><a href=\"\/en\/adel-y04\">ADEL-Y04<\/a><\/li>\n<\/ul><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-1{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 60px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 126px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-1{width:100% !important;order : 0;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 40px !important;margin-right : 0;padding-bottom : 100px !important;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-1{width:100% !important;order : 0;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 32px !important;margin-right : 0;padding-bottom : 48px !important;margin-left : 0;}}<\/style><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"2.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 125px 0px;\"><div class=\"pipeline_box_wrap\">\n    <div class=\"pipeline_box pipeline_box_title\">\n        <h3 class=\"pipeline_box_h3\">ADEL-Y04<\/h3>\n        <p class=\"pipeline_h3_txt\">ApoE4 antibody<\/p>\n    <\/div>\n    <div class=\"pipeline_box\">\n        <h4 class=\"pipeline_box_h4\">Target Type<\/h4>\n        <p class=\"pipeline_box_txt\">ApoE4<\/p>\n    <\/div>\n    <div class=\"pipeline_box\">\n        <h4 class=\"pipeline_box_h4\">Indication<\/h4>\n        <p class=\"pipeline_box_txt\">Alzheimer\u2019s Disease, <br \/>Metabolic disease<\/p>\n    <\/div>\n    <div class=\"pipeline_box\">\n        <h4 class=\"pipeline_box_h4\">Development stage<\/h4>\n        <p class=\"pipeline_box_txt\">Preclinical efficacy<\/p>\n    <\/div>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-2{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-2 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 125px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 0;padding-bottom : 80px !important;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 0;padding-bottom : 56px !important;margin-left : 0;}}<\/style><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-2{ padding-top : 0px;margin-top : 0px;padding-right : 0px;padding-bottom : 0px;margin-bottom : 0px;padding-left : 0px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#e2e2e2;border-style:solid;\"><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:calc( 1300px + 0px );margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_1 1_1 fusion-flex-column h3_col fusion-animated\" data-animationType=\"fadeInDown\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 40px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-1{margin-top:0px!important;margin-bottom:0px!important;}}@media only screen and (max-width:777px) {.fusion-title.fusion-title-1{margin-top:0px!important;margin-bottom:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-three h3_box\" style=\"margin-top:0px;margin-bottom:0px;\"><h3 class=\"title-heading-left\" style=\"margin:0;\">Target<\/h3><\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-3{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-3 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 40px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 0;padding-bottom : 24px !important;margin-left : 0;}}<\/style><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-2 pipeline_con_txtbox\"><p><strong class=\"pipeline5_strong\">Apolipoprotein E4 (ApoE4)<\/strong><\/p>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-4{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-4 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}<\/style><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-5 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-3 pipeline4_con_txtbox\"><ul class=\"pipeline_con_txtbox_list\">\n<li>The strongest genetic risk factor for AD (two copies of the ApoE4 variant increase the risk by up to 12 times) <\/li>\n<\/ul>\n<\/div><div class=\"pipeline_img_wrap\">\n    <div class=\"pipeline_imgbox\">\n        <div class=\"pipeline_img\"><img src=\"\/wp-content\/uploads\/pipeline4_img2-1.png\" alt=\"Apolipoprotein E4\"\/><\/div>\n    <\/div>\n    <div class=\"pipeline_imgbox\">\n        <div class=\"pipeline_img\"><img src=\"\/wp-content\/uploads\/pipeline4_img2-2.png\" alt=\"Apolipoprotein E4\"\/><\/div>\n    <\/div>\n<\/div><div class=\"fusion-text fusion-text-4 pipeline4_con1_refer\" style=\"text-align:right;\"><p>Lane CA et al., Eur. J. Neurol. 25(1): 59, 2018)<\/p>\n<\/div><div class=\"fusion-text fusion-text-5\"><ul class=\"pipeline_con_txtbox_list\">\n<li>Aggravates b-amyloid accumulation and tau pathology <\/li>\n<li>Has a higher propensity for self-aggregation and less efficient in lipid metabolism compared to the E3 and E2 variants<\/li>\n<li>Known to induce inflammation, damage the blood-brain barrier, and increase the risk of heart disease.<\/li>\n<\/ul>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-5{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-5 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}<\/style><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-top : 0px;margin-top : 0px;padding-right : 0px;padding-bottom : 130px;margin-bottom : 0px;padding-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-bottom : 100px;}}@media only screen and (max-width:777px) {.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-bottom : 70px;}}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-4 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#e2e2e2;border-style:solid;\"><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:calc( 1300px + 0px );margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-6 fusion_builder_column_1_1 1_1 fusion-flex-column h3_col fusion-animated\" data-animationType=\"fadeInDown\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 40px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-2{margin-top:0px!important;margin-bottom:0px!important;}}@media only screen and (max-width:777px) {.fusion-title.fusion-title-2{margin-top:0px!important;margin-bottom:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-text fusion-title-size-three h3_box\" style=\"margin-top:0px;margin-bottom:0px;\"><h3 class=\"title-heading-left\" style=\"margin:0;\">Summary<\/h3><\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-6{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-6 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 40px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 0;padding-bottom : 24px !important;margin-left : 0;}}<\/style><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-7 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-6\"><p>Reduce tau and inflammation and improve synapses and cognitive dysfunction in ApoE4-expressing AD model<\/p>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-7{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-7 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-7{width:100% !important;order : 0;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-7{width:100% !important;order : 0;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}<\/style><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-4{ padding-top : 0px;margin-top : 0px;padding-right : 0px;padding-bottom : 130px;margin-bottom : 0px;padding-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-flex-container.fusion-builder-row-4{ padding-bottom : 100px;}}@media only screen and (max-width:777px) {.fusion-body .fusion-flex-container.fusion-builder-row-4{ padding-bottom : 70px;}}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-5 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#e2e2e2;border-style:solid;\"><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:calc( 1300px + 0px );margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-8 fusion_builder_column_1_1 1_1 fusion-flex-column h3_col fusion-animated\" data-animationType=\"fadeInDown\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 40px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-3{margin-top:0px!important;margin-bottom:0px!important;}}@media only screen and (max-width:777px) {.fusion-title.fusion-title-3{margin-top:0px!important;margin-bottom:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-3 fusion-sep-none fusion-title-text fusion-title-size-three h3_box\" style=\"margin-top:0px;margin-bottom:0px;\"><h3 class=\"title-heading-left\" style=\"margin:0;\">Competitive advantages<\/h3><\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-8{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-8 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 40px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-8{width:100% !important;order : 0;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-8{width:100% !important;order : 0;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 0;padding-bottom : 24px !important;margin-left : 0;}}<\/style><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-9 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-7\"><ul class=\"pipeline_con_txtbox_list\">\n<li>Binds specifically to ApoE4 protein <\/li>\n<li>High binding affinity to ApoE4 aggregates compared to competitive anti-ApoE4 antibody<\/li>\n<\/ul>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-9{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-9 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-9{width:100% !important;order : 0;}.fusion-builder-column-9 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-9{width:100% !important;order : 0;}.fusion-builder-column-9 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}<\/style><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-5{ padding-top : 0px;margin-top : 0px;padding-right : 0px;padding-bottom : 130px;margin-bottom : 0px;padding-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-flex-container.fusion-builder-row-5{ padding-bottom : 100px;}}@media only screen and (max-width:777px) {.fusion-body .fusion-flex-container.fusion-builder-row-5{ padding-bottom : 70px;}}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-6 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#e2e2e2;border-style:solid;\"><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:calc( 1300px + 0px );margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-10 fusion_builder_column_1_1 1_1 fusion-flex-column h3_col fusion-animated\" data-animationType=\"fadeInDown\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 40px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-4{margin-top:0px!important;margin-bottom:0px!important;}}@media only screen and (max-width:777px) {.fusion-title.fusion-title-4{margin-top:0px!important;margin-bottom:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-4 fusion-sep-none fusion-title-text fusion-title-size-three h3_box\" style=\"margin-top:0px;margin-bottom:0px;\"><h3 class=\"title-heading-left\" style=\"margin:0;\">Development stage<\/h3><\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-10{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-10 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 40px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-10{width:100% !important;order : 0;}.fusion-builder-column-10 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-10{width:100% !important;order : 0;}.fusion-builder-column-10 > .fusion-column-wrapper {margin-right : 0;padding-bottom : 24px !important;margin-left : 0;}}<\/style><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-11 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-8 pipeline_con_txtbox\"><ul class=\"pipeline_con_txtbox_list\">\n<li>Obtain a clone<\/li>\n<li>In vivo safety and efficacy<\/li>\n<\/ul>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-11{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-11 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-11{width:100% !important;order : 0;}.fusion-builder-column-11 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-11{width:100% !important;order : 0;}.fusion-builder-column-11 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}<\/style><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-12 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"pipeline_dep_stage\">\n    <ul class=\"pipeline_dep_header\">\n        <li>Pipelines<\/li>\n        <li>Discovery<\/li>\n        <li>Preclinical<\/li>\n        <li>Clinical<\/li>\n    <\/ul>\n    <div class=\"pipeline_dep_content_wrap\">\n        <div class=\"pipeline_dep_titlebox\">\n            <h4 class=\"pipeline_dep_h4\">ADEL-Y04<\/h4>\n            <p class=\"pipeline_dep_h4_txt\">ApoE4-target<\/p>\n        <\/div>\n        <div class=\"pipeline_dep_stage_box\">\n            <div class=\"pipeline_dep_stage_bar_box\">\n                <div class=\"pipeline_dep_stage_bar\">\n                    <div class=\"pipeline_dep_m\">\n                        <p class=\"pipeline_stage_title\">Discovery<\/p>\n                        <div class=\"pipeline_stage_mark\"><span class=\"sr_only\">mark<\/span><\/div>\n                    <\/div>\n                <\/div>\n                <div class=\"pipeline_dep_stage_bar\">\n                    <div class=\"pipeline_dep_m\">\n                        <p class=\"pipeline_stage_title\">Preclinical<\/p>\n                    <\/div>\n                <\/div>\n                <div class=\"pipeline_dep_stage_bar\">\n                    <div class=\"pipeline_dep_m\">\n                        <p class=\"pipeline_stage_title\">Clinical<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n            <div class=\"pipeline_dep_progress_box pipeline_dep_progress_box1\">\n                <div class=\"pipeline_dep_progress_bar\"><span class=\"sr_only\">Preclinical<\/span><\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-12{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-12 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-12{width:100% !important;order : 0;}.fusion-builder-column-12 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-12{width:100% !important;order : 0;}.fusion-builder-column-12 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}<\/style><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-6{ padding-top : 0px;margin-top : 0px;padding-right : 0px;padding-bottom : 200px;margin-bottom : 0px;padding-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-flex-container.fusion-builder-row-6{ padding-bottom : 140px;}}@media only screen and (max-width:777px) {.fusion-body .fusion-flex-container.fusion-builder-row-6{ padding-bottom : 100px;}}<\/style><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>ADEL-Y04 - ADEL<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/adelpharm.com\/en\/adel-y04\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ADEL-Y04 - ADEL\" \/>\n<meta property=\"og:url\" content=\"https:\/\/adelpharm.com\/en\/adel-y04\/\" \/>\n<meta property=\"og:site_name\" content=\"ADEL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ADELpharmaceutical\" \/>\n<meta property=\"article:modified_time\" content=\"2023-10-19T04:06:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/adelpharm.com\/wp-content\/uploads\/adel_seo.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"35 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/adelpharm.com\/en\/adel-y04\/\",\"url\":\"https:\/\/adelpharm.com\/en\/adel-y04\/\",\"name\":\"ADEL-Y04 - ADEL\",\"isPartOf\":{\"@id\":\"https:\/\/adelpharm.com\/#website\"},\"datePublished\":\"2023-10-18T02:14:48+00:00\",\"dateModified\":\"2023-10-19T04:06:04+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/adelpharm.com\/en\/adel-y04\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/adelpharm.com\/en\/adel-y04\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/adelpharm.com\/en\/adel-y04\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/adelpharm.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"ADEL-Y04\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/adelpharm.com\/#website\",\"url\":\"https:\/\/adelpharm.com\/\",\"name\":\"ADEL\",\"description\":\"ADEL, We dream of a world without dementia.\",\"publisher\":{\"@id\":\"https:\/\/adelpharm.com\/#organization\"},\"alternateName\":\"ADEL\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/adelpharm.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/adelpharm.com\/#organization\",\"name\":\"ADEL\",\"alternateName\":\"ADEL\",\"url\":\"https:\/\/adelpharm.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/adelpharm.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/adelpharm.com\/wp-content\/uploads\/logo2x_sticky.png\",\"contentUrl\":\"https:\/\/adelpharm.com\/wp-content\/uploads\/logo2x_sticky.png\",\"width\":258,\"height\":66,\"caption\":\"ADEL\"},\"image\":{\"@id\":\"https:\/\/adelpharm.com\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/ADELpharmaceutical\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"ADEL-Y04 - ADEL","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/adelpharm.com\/en\/adel-y04\/","og_locale":"en_US","og_type":"article","og_title":"ADEL-Y04 - ADEL","og_url":"https:\/\/adelpharm.com\/en\/adel-y04\/","og_site_name":"ADEL","article_publisher":"https:\/\/www.facebook.com\/ADELpharmaceutical","article_modified_time":"2023-10-19T04:06:04+00:00","og_image":[{"width":1200,"height":675,"url":"https:\/\/adelpharm.com\/wp-content\/uploads\/adel_seo.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"35 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/adelpharm.com\/en\/adel-y04\/","url":"https:\/\/adelpharm.com\/en\/adel-y04\/","name":"ADEL-Y04 - ADEL","isPartOf":{"@id":"https:\/\/adelpharm.com\/#website"},"datePublished":"2023-10-18T02:14:48+00:00","dateModified":"2023-10-19T04:06:04+00:00","breadcrumb":{"@id":"https:\/\/adelpharm.com\/en\/adel-y04\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/adelpharm.com\/en\/adel-y04\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/adelpharm.com\/en\/adel-y04\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/adelpharm.com\/en\/"},{"@type":"ListItem","position":2,"name":"ADEL-Y04"}]},{"@type":"WebSite","@id":"https:\/\/adelpharm.com\/#website","url":"https:\/\/adelpharm.com\/","name":"ADEL","description":"ADEL, We dream of a world without dementia.","publisher":{"@id":"https:\/\/adelpharm.com\/#organization"},"alternateName":"ADEL","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/adelpharm.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/adelpharm.com\/#organization","name":"ADEL","alternateName":"ADEL","url":"https:\/\/adelpharm.com\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/adelpharm.com\/#\/schema\/logo\/image\/","url":"https:\/\/adelpharm.com\/wp-content\/uploads\/logo2x_sticky.png","contentUrl":"https:\/\/adelpharm.com\/wp-content\/uploads\/logo2x_sticky.png","width":258,"height":66,"caption":"ADEL"},"image":{"@id":"https:\/\/adelpharm.com\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/ADELpharmaceutical"]}]}},"_links":{"self":[{"href":"https:\/\/adelpharm.com\/en\/wp-json\/wp\/v2\/pages\/761"}],"collection":[{"href":"https:\/\/adelpharm.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/adelpharm.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/adelpharm.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/adelpharm.com\/en\/wp-json\/wp\/v2\/comments?post=761"}],"version-history":[{"count":5,"href":"https:\/\/adelpharm.com\/en\/wp-json\/wp\/v2\/pages\/761\/revisions"}],"predecessor-version":[{"id":826,"href":"https:\/\/adelpharm.com\/en\/wp-json\/wp\/v2\/pages\/761\/revisions\/826"}],"wp:attachment":[{"href":"https:\/\/adelpharm.com\/en\/wp-json\/wp\/v2\/media?parent=761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}