{"id":755,"date":"2023-10-18T11:11:33","date_gmt":"2023-10-18T02:11:33","guid":{"rendered":"https:\/\/adelpharm.mycafe24.com\/?page_id=755"},"modified":"2023-10-19T16:55:16","modified_gmt":"2023-10-19T07:55:16","slug":"adel-y01","status":"publish","type":"page","link":"https:\/\/adelpharm.com\/en\/adel-y01\/","title":{"rendered":"ADEL-Y01"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container fusion-parallax-none nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-image: url(&quot;https:\/\/adelpharm.com\/wp-content\/uploads\/pipeline_subbanner_bg.jpg&quot;);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#e2e2e2;border-style:solid;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;\" id=\"subbanner\"><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:calc( 1300px + 0px );margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInDown\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-1\" style=\"text-align:center;\" id=\"subbanner_txtbox\"><p class=\"page_parent\">Pipeline<\/p>\n<h1 class=\"page_h1\">ADEL-Y01<\/h1>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-0{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-0 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-0{width:100% !important;order : 0;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-0{width:100% !important;order : 0;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}<\/style><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 230px;margin-top : 0px;padding-right : 0px;padding-bottom : 0px;margin-bottom : 0px;padding-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 210px;}}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#e2e2e2;border-style:solid;\" id=\"subpage_con1\"><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:calc( 1300px + 0px );margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;background-color:#ffffff;padding: 60px 0px 126px 0px;\"><ul class=\"breadcrumbs_list\">\n    <li><a href=\"\/en\/home\" class=\"bread_home\"><span class=\"sr_only\">HOME<\/span><\/a><\/li>\n    <li><a href=\"\/en\/pipeline\">PIPELINE<\/a><\/li>\n    <li><a href=\"\/en\/adel-y01\">ADEL-Y01<\/a><\/li>\n<\/ul><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-1{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 60px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 126px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-1{width:100% !important;order : 0;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 40px !important;margin-right : 0;padding-bottom : 100px !important;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-1{width:100% !important;order : 0;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 32px !important;margin-right : 0;padding-bottom : 48px !important;margin-left : 0;}}<\/style><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"2.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 125px 0px;\"><div class=\"pipeline_box_wrap\">\n    <div class=\"pipeline_box pipeline_box_title\">\n        <h3 class=\"pipeline_box_h3\">ADEL-Y01<\/h3>\n        <p class=\"pipeline_h3_txt\">Tau acK280 antibody<\/p>\n    <\/div>\n    <div class=\"pipeline_box\">\n        <h4 class=\"pipeline_box_h4\">Target Type<\/h4>\n        <p class=\"pipeline_box_txt\">Tau (acetylated lysine 280, acK280)<\/p>\n    <\/div>\n    <div class=\"pipeline_box\">\n        <h4 class=\"pipeline_box_h4\">Indication<\/h4>\n        <p class=\"pipeline_box_txt\">Alzheimer's disease or Tauopathy (rare disease)<\/p>\n    <\/div>\n    <div class=\"pipeline_box\">\n        <h4 class=\"pipeline_box_h4\">Development stage<\/h4>\n        <p class=\"pipeline_box_txt\">Clinical, phase 1 (USA FDA)<\/p>\n    <\/div>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-2{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-2 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 125px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 0;padding-bottom : 80px !important;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 0;padding-bottom : 56px !important;margin-left : 0;}}<\/style><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-2{ padding-top : 0px;margin-top : 0px;padding-right : 0px;padding-bottom : 0px;margin-bottom : 0px;padding-left : 0px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#e2e2e2;border-style:solid;\"><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:calc( 1300px + 0px );margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_1 1_1 fusion-flex-column h3_col fusion-animated\" data-animationType=\"fadeInDown\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 40px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-1{margin-top:0px!important;margin-bottom:0px!important;}}@media only screen and (max-width:777px) {.fusion-title.fusion-title-1{margin-top:0px!important;margin-bottom:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-three h3_box\" style=\"margin-top:0px;margin-bottom:0px;\"><h3 class=\"title-heading-left\" style=\"margin:0;\">Related Figures and\/or Summary<\/h3><\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-3{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-3 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 40px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-3{width:100% !important;order : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 0;padding-bottom : 24px !important;margin-left : 0;}}<\/style><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"y01_con1_wrap\">\n    <div class=\"y01_con1_txtbox\">\n        <p class=\"y01_con1_title\">Unveiling the Crucial Role of Tau-K280 Acetylation in Disease Pathogenesis<\/p>\n        <p><sup>275<\/sup>VQIINK<sup>280<\/sup> is a critical motif for tau aggregation of MTBR (microtubule binding repeat).<\/p>\n    <\/div>\n    <div class=\"pipeline_img_wrap\">\n        <div class=\"pipeline_imgbox\">\n            <div class=\"pipeline_img\"><img src=\"\/wp-content\/uploads\/y01_con1_img1-v2.jpg\" alt=\"Unveiling the Crucial Role of Tau-K280 Acetylation in Disease Pathogenesis\"\/><\/div>\n        <\/div>\n        <div class=\"pipeline_imgbox\">\n            <div class=\"pipeline_img\"><img src=\"\/wp-content\/uploads\/y01_con1_img2-v2.jpg\" alt=\"Unveiling the Crucial Role of Tau-K280 Acetylation in Disease Pathogenesis\"\/><\/div>\n        <\/div>\n    <\/div>\n    <ul class=\"pipeline_con_txtbox_list\">\n        <li>At the heart of disease pathogenesis lies the pivotal acetylation of tau at K280 (tau-acK280). The hexapeptide sequence <sup>275<\/sup>VQIINK<sup>280<\/sup>, which encompasses the K280 residue within tau's microtubule binding repeat (MTBR), emerges as a critical motif driving tau aggregation (1).<\/li>\n        <li>The tau-acK280 modification has been identified in tauopathies associated with AD and other neurodegenerative disorders (2). Remarkably, patients afflicted by FTDP-17, who lack the K280 residue, manifest tau deposits in the brain (3). This underscore the profound implication that absence or alteration of tau K280 precipitates tauopathies in neurodegenerative conditions. This emphasizes the non-negotiable role of K280 in maintaining tau's native functions within neurons, as deviation leads to the irreversible conversion into proteopathic tau. <\/li>\n        <li>Tau-acK280 promotes the formation of short fibrillar aggregates, measuring shorter than 200 nm. This phenomenon may augment the seeding capacity and toxicity of tau species in vivo (4).<\/li>\n    <\/ul>\n    <ul class=\"y01_con1_ref\">\n        <li>1. <i>J Biol Chem.<\/i> 2005;280(26):24978-86.<\/li>\n        <li>2. <i>Nat Commun.<\/i> 2011;2:252.<\/li>\n        <li>3. <i>Am J Hum Genet.<\/i> 1999;64(2):414-21.<\/li>\n        <li>4. <i>J Am Chem Soc.<\/i> 2018;140(21):6611-21.<\/li>\n    <\/ul>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-4{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-4 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-4{width:100% !important;order : 0;}.fusion-builder-column-4 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}<\/style><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-top : 0px;margin-top : 0px;padding-right : 0px;padding-bottom : 130px;margin-bottom : 0px;padding-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-bottom : 100px;}}@media only screen and (max-width:777px) {.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-bottom : 70px;}}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-4 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#e2e2e2;border-style:solid;\"><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:calc( 1300px + 0px );margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-5 fusion_builder_column_1_1 1_1 fusion-flex-column h3_col fusion-animated\" data-animationType=\"fadeInDown\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 40px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-2{margin-top:0px!important;margin-bottom:0px!important;}}@media only screen and (max-width:777px) {.fusion-title.fusion-title-2{margin-top:0px!important;margin-bottom:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-text fusion-title-size-three h3_box\" style=\"margin-top:0px;margin-bottom:0px;\"><h3 class=\"title-heading-left\" style=\"margin:0;\">Unrivaled Excellence in Action<\/h3><\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-5{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-5 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 40px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-5{width:100% !important;order : 0;}.fusion-builder-column-5 > .fusion-column-wrapper {margin-right : 0;padding-bottom : 24px !important;margin-left : 0;}}<\/style><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-6 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-2\"><p>Discover Y01, the pinnacle of antibody efficacy that outshines its competitors.<\/p>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-6{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-6 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}<\/style><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-7 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\" id=\"y01_con2_txt_col\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"y01_con2_wrap\">\n    <div class=\"pipeline_img_wrap\">\n        <div class=\"pipeline_imgbox pipeline_imgbox100\">\n            <h4 class=\"pipeline_imgbox_h4\">A. Elevating the Bar in Tau Seeding\/Propagation Inhibition<\/h4>\n            <div class=\"pipeline_adv_content\">\n                <div class=\"pipeline_adv_txtbox\">\n                    <p>Witness the remarkable prowess of Y01 as it takes the lead in inhibiting tau seeding. When tested on insoluble tau aggregates from AD brains within HEK-Tau-RD-P301S cells, Y01 reigns supreme in its inhibition, surpassing the impact of other antibodies<\/p>\n                <\/div>\n                <div class=\"pipeline_adv_imgbox\"><img src=\"\/wp-content\/uploads\/y01_con2_img1.jpg\" alt=\"A. Elevating the Bar in Tau Seeding\/Propagation Inhibition\"\/><\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n    <div class=\"pipeline_img_wrap\">\n        <div class=\"pipeline_imgbox pipeline_imgbox100\">\n            <h4 class=\"pipeline_imgbox_h4\">B. Mastering the Art of Tau Aggregation Inhibition<\/h4>\n            <div class=\"pipeline_adv_content\">\n                <div class=\"pipeline_adv_txtbox\">\n                    <p>Y01's superiority in inhibiting tau aggregation is unparalleled. As demonstrated in the Thioflavin-T assay of acetylated Tau (acTau), Y01 emerges as the foremost guardian against tau aggregation, leaving other antibodies in its wake.<\/p>\n                <\/div>\n                <div class=\"pipeline_adv_imgbox\"><img src=\"\/wp-content\/uploads\/y01_con2_img2.jpg\" alt=\"B. Mastering the Art of Tau Aggregation Inhibition\"\/><\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n    <div class=\"pipeline_img_wrap\">\n        <div class=\"pipeline_imgbox pipeline_imgbox100\">\n            <h4 class=\"pipeline_imgbox_h4\">C. Empowering Microglial Tau Clearance<\/h4>\n            <div class=\"pipeline_adv_content\">\n                <div class=\"pipeline_adv_txtbox\">\n                    <p>Observe the dynamic enhancement of microglial tau clearance driven by Y01. Through meticulous quantification of BV2 microglial cells, we unveil Y01's distinctive ability to induce tau aggregate uptake, surpassing the performance of other antibodies.<\/p>\n                <\/div>\n                <div class=\"pipeline_adv_imgbox\"><img src=\"\/wp-content\/uploads\/y01_con2_img3.jpg\" alt=\"C. Empowering Microglial Tau Clearance\"\/><\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div><div class=\"fusion-text fusion-text-3 y01_con2_txtbox\"><p>Y01 stands as the epitome of excellence, redefining the boundaries of antibody efficacy in the field. Experience its supremacy and embrace the future of innovative solutions.<\/p>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-7{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-7 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-7{width:100% !important;order : 0;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-7{width:100% !important;order : 0;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}<\/style><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-4{ padding-top : 0px;margin-top : 0px;padding-right : 0px;padding-bottom : 130px;margin-bottom : 0px;padding-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-flex-container.fusion-builder-row-4{ padding-bottom : 100px;}}@media only screen and (max-width:777px) {.fusion-body .fusion-flex-container.fusion-builder-row-4{ padding-bottom : 70px;}}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-5 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#e2e2e2;border-style:solid;\"><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:calc( 1300px + 0px );margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-8 fusion_builder_column_1_1 1_1 fusion-flex-column h3_col fusion-animated\" data-animationType=\"fadeInDown\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 40px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-3{margin-top:0px!important;margin-bottom:0px!important;}}@media only screen and (max-width:777px) {.fusion-title.fusion-title-3{margin-top:0px!important;margin-bottom:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-3 fusion-sep-none fusion-title-text fusion-title-size-three h3_box\" style=\"margin-top:0px;margin-bottom:0px;\"><h3 class=\"title-heading-left\" style=\"margin:0;\">Development stage<\/h3><\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-8{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-8 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 40px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-8{width:100% !important;order : 0;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-8{width:100% !important;order : 0;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 0;padding-bottom : 24px !important;margin-left : 0;}}<\/style><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-9 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-4 pipeline_con_txtbox\"><p>IND approval, entry into Phase 1 clinical trial (4Q, 2023)<\/p>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-9{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-9 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-9{width:100% !important;order : 0;}.fusion-builder-column-9 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-9{width:100% !important;order : 0;}.fusion-builder-column-9 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}<\/style><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-10 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"pipeline_dep_stage\">\n    <ul class=\"pipeline_dep_header\">\n        <li>Pipelines<\/li>\n        <li>Discovery<\/li>\n        <li>Preclinical<\/li>\n        <li>Clinical<\/li>\n    <\/ul>\n    <div class=\"pipeline_dep_content_wrap\">\n        <div class=\"pipeline_dep_titlebox\">\n            <h4 class=\"pipeline_dep_h4\">ADEL-Y01<\/h4>\n            <p class=\"pipeline_dep_h4_txt\">Tau antibody<\/p>\n        <\/div>\n        <div class=\"pipeline_dep_stage_box\">\n            <div class=\"pipeline_dep_stage_bar_box\">\n                <div class=\"pipeline_dep_stage_bar\">\n                    <div class=\"pipeline_dep_m\">\n                        <p class=\"pipeline_stage_title\">Discovery<\/p>\n                        <div class=\"pipeline_stage_mark\"><span class=\"sr_only\">mark<\/span><\/div>\n                    <\/div>\n                <\/div>\n                <div class=\"pipeline_dep_stage_bar\">\n                    <div class=\"pipeline_dep_m\">\n                        <p class=\"pipeline_stage_title\">Preclinical<\/p>\n                        <div class=\"pipeline_stage_mark\"><span class=\"sr_only\">mark<\/span><\/div>\n                    <\/div>\n                <\/div>\n                <div class=\"pipeline_dep_stage_bar\">\n                    <div class=\"pipeline_dep_m\">\n                        <p class=\"pipeline_stage_title\">Clinical<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n            <div class=\"pipeline_dep_progress_box pipeline_dep_progress_box2\">\n                <div class=\"pipeline_dep_progress_bar\"><span class=\"sr_only\">Preclinical<\/span><\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-10{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-10 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-10{width:100% !important;order : 0;}.fusion-builder-column-10 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-10{width:100% !important;order : 0;}.fusion-builder-column-10 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}<\/style><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-5{ padding-top : 0px;margin-top : 0px;padding-right : 0px;padding-bottom : 130px;margin-bottom : 0px;padding-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-flex-container.fusion-builder-row-5{ padding-bottom : 100px;}}@media only screen and (max-width:777px) {.fusion-body .fusion-flex-container.fusion-builder-row-5{ padding-bottom : 70px;}}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-6 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#e2e2e2;border-style:solid;\"><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:calc( 1300px + 0px );margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-11 fusion_builder_column_1_1 1_1 fusion-flex-column h3_col fusion-animated\" data-animationType=\"fadeInDown\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-4{margin-top:0px!important;margin-bottom:0px!important;}}@media only screen and (max-width:777px) {.fusion-title.fusion-title-4{margin-top:0px!important;margin-bottom:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-4 fusion-sep-none fusion-title-text fusion-title-size-three h3_box\" style=\"margin-top:0px;margin-bottom:0px;\"><h3 class=\"title-heading-left\" style=\"margin:0;\">Related papers and patents<\/h3><\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-11{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-11 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-11{width:100% !important;order : 0;}.fusion-builder-column-11 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-11{width:100% !important;order : 0;}.fusion-builder-column-11 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}<\/style><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-12 fusion_builder_column_1_1 1_1 fusion-flex-column pipeline_papers_col fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 33px 0px 40px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-5{margin-top:0px!important;margin-bottom:0px!important;}}@media only screen and (max-width:777px) {.fusion-title.fusion-title-5{margin-top:0px!important;margin-bottom:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-5 fusion-sep-none fusion-title-text fusion-title-size-four pipeline_papers_titlebox\" style=\"margin-top:0px;margin-bottom:0px;\"><h4 class=\"title-heading-left\" style=\"margin:0;\">Papers<\/h4><\/div><div class=\"fusion-text fusion-text-5 pipeline_papers_txtbox\"><div class=\"relate_box\">\n<p class=\"relate_txt\">Song HL, Kim NY, Park J, Kim MI, Jeon YN, Lee SJ, Cho K, Shim YL, Lee KH, Mun YS, Song JA, Kim MS, Pack CG, Jung M, Jang H, Na DL, Hong M, Kim DH, Yoon SY. Monoclonal antibody Y01 prevents tauopathy progression induced by lysine 280-acetylated tau in cell and mouse models. J Clin Invest. 2023 Apr 17;133(8):e156537. doi: 10.1172\/JCI156537. PMID: 36917188; PMCID: PMC10104896.<\/p>\n<div class=\"relate_imgbox\"><a href=\"https:\/\/www.jci.org\/articles\/view\/156537\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"\/wp-content\/uploads\/y01_paper_img.jpg\" alt=\"Monoclonal antibody Y01 prevents tauopathy progression induced by lysine 280-acetylated tau in cell and mouse models.\" \/><\/a><\/div>\n<\/div>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-12{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-12 > .fusion-column-wrapper {padding-top : 33px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 40px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-12{width:100% !important;order : 0;}.fusion-builder-column-12 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-12{width:100% !important;order : 0;}.fusion-builder-column-12 > .fusion-column-wrapper {padding-top : 20px !important;margin-right : 0;padding-bottom : 24px !important;margin-left : 0;}}<\/style><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-13 fusion_builder_column_1_1 1_1 fusion-flex-column pipeline_papers_col fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"100%\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 33px 0px 40px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-6{margin-top:0px!important;margin-bottom:0px!important;}}@media only screen and (max-width:777px) {.fusion-title.fusion-title-6{margin-top:0px!important;margin-bottom:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-6 fusion-sep-none fusion-title-text fusion-title-size-four pipeline_papers_titlebox\" style=\"margin-top:0px;margin-bottom:0px;\"><h4 class=\"title-heading-left\" style=\"margin:0;\">Patents<\/h4><\/div><div class=\"fusion-text fusion-text-6 pipeline_papers_txtbox\"><p>Anti-tau antibody and use of same (WO2021010712A1)<\/p>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-13{width:100% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-13 > .fusion-column-wrapper {padding-top : 33px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 40px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-13{width:100% !important;order : 0;}.fusion-builder-column-13 > .fusion-column-wrapper {margin-right : 0;margin-left : 0;}}@media only screen and (max-width:777px) {.fusion-body .fusion-builder-column-13{width:100% !important;order : 0;}.fusion-builder-column-13 > .fusion-column-wrapper {padding-top : 20px !important;margin-right : 0;padding-bottom : 24px !important;margin-left : 0;}}<\/style><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-6{ padding-top : 0px;margin-top : 0px;padding-right : 0px;padding-bottom : 200px;margin-bottom : 0px;padding-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-flex-container.fusion-builder-row-6{ padding-bottom : 140px;}}@media only screen and (max-width:777px) {.fusion-body .fusion-flex-container.fusion-builder-row-6{ padding-bottom : 100px;}}<\/style><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.5 - 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