Platform
ADTAC™
ADTAC™
Autophagic Degradation Targeting Chimera
- Protein
Aggregates - Lipids
- Organelles
What is ADTAC™
- Deliver target molecules to the LC3 domain
- Degrade through autophagy
- Degrade even big-sized protein aggregates
Competitive advantages
Comparison Autophagy-lysosome is a major intracellular degradation system.
| ADEL | PROTAC | autophagy | ||
|---|---|---|---|---|
| Target substrates |
Protein (soluble) | O | O | O |
| Protein (large aggregates) | O | X | O | |
| Others (lipids, DNA/RNA) | O | X | O | |
| Cellular organelles | O | X | O | |
| MOA | Independent on E3-ligase, proteasome activity | O | X | O |
| Direct targeting to autophagosome/lysosome | O | X | X | |
| Easy binding with the existing target binder | O | X | X | |
- ADTAC can degrade not only soluble proteins but also highly misfolded proteins or large-sized aggregates or lipids or even pathogens.
- ADTAC can degrade damaged organelles
- ADTAC is independent on proteasome activity
- ADTAC is independent on E3-ligase